Endothelial Dysfunctions in Vascular Disease

Bridging the gap between the laboratory and the bedside, this timely volume illuminates the connection between endothelial dysfunction and vascular disease. This comprehensive survey of atherosclerotic disease begins with biology - incorporating the latest breakthroughs in the field - then elucidates risk factors and diagnostic tools and markers. A major section on endothelium-directed prevention and therapy shows you how to apply cutting-edge research to clinical care.Under the careful editorial guidance of Drs. De Caterina and Libby, the highly-regarded contributors address: endothelial activation and the initiation of atherosclerosis, mechanisms of plaque progression and complications, the role of LDL in the origin and progression of atherosclerosis, advanced glycation endproducts and the accelerated atherosclerosis in diabetes, oxidative stress and vascular disease, soluble adhesion molecules as markers of vascular disease, hormone-replacement therapy and cardiovascular risk, anti-oxidants and endothelial protection, and more.The first book dedicated to the central role of endothelial dysfunction in vascular disease, this concise volume gathers all the latest information on the subject into one convenient and cohesive text. It makes sure your patients are benefiting from current knowledge by keeping a copy of Enothelial Dysfunctions in Vascular Disease close at hand for frequent consultation. Every book has a history, this one not excepted, having emerged from intersections in professional lives of the Editors.This book bears the fruits of a collaboration between the 'pupil' (RDC) and the 'mentor' (PL). During an extended sabbatical of the pupil in Boston in 1994, we probed together the concept that endothelial dysfunction served as a common denominator of vascular disease, with the balance between inflammation and its inhibition as a fulcrum of the regulation of the behavior of endothelial cells. As practicing cardiologists in our clinical lives, we sought to